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Structure-based Drug Discovery by Harren Jhoti & Andrew Leach
Describes the developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book. The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications. |
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| Author(s) : Andrew Leach | Format : Hardback Book |
| ISBN-10 : 1402044062 | ISBN-13 : 9781402044069 |
| RRP : £100.00 | Best available price : £ / $ |
| Prices as of : BST check live prices | |
Product Details:
Country Publication : Netherlands
Publication Date : 01/05/2006
Publisher : Kluwer Academic Publishers Group
Page Length : XII, 249mm