Macrophages in Anti-Inflammation by S. Goerdt & Constantin E. Orfanos

Molecular Mechanisms, Apoptosis, and Tolerance Induction, 2nd Teupitzer Colloquium, September 1999

The anti-inflammatory mechanisms have moved to the forefront of inflammation research. Anti-inflammatory mechanisms function in various ways: they protect against unwanted immune reactions and contain inflammatory reactions once these are induced. Finally, they secure down regulation and healing after the successful elimination of a noxious agent. During the last two decades, anti-inflammatory mechanisms have moved from a neglected field of immunology to the forefront of inflammation research. Anti-inflammatory mechanisms function in various ways: they protect against unwanted immune reactions and contain inflammatory reactions once these are induced. Finally, they secure down regulation and healing after the successful elimination of a noxious agent. Specialized, alternatively activated macrophages play a major role in these processes. Alternatively activated macrophages tend toward preferential secretion of anti-inflammatory cytokines; are capable of removing apoptotic cells and tissue debris without inflammation; and can - along with deactivated immature dendritic cells - deliver tolerance signals to T-cells. Thus, anti-inflammatory macrophages are attractive candidates for a cell-based vaccination therapy of allergic and autoimmune diseases.
Author(s) : Constantin E. Orfanos	Format : Paperback Book
ISBN-10 : 3805570619	ISBN-13 : 9783805570619
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